Rejuran for First-Timers in Shinsaibashi, Osaka: Choosing a Clinic with Peace of Mind
As skin loses firmness and glow with age and fine lines and dullness from dryness become noticeable, skincare alone can start to feel insufficient. One option attracting attention at such times is “Rejuran injection,” which works on the skin’s regenerative power.
However, for people new to aesthetic medicine, it is not uncommon to feel anxious, wondering “does it really work?”, “what about pain and side effects?”, and “where can I receive it with peace of mind?”
In this article, while explaining in an easy-to-understand way the basic effects of Rejuran and how it differs from other aesthetic treatments, we introduce points to keep in mind when choosing an aesthetic dermatology clinic in the Shinsaibashi area. We hope it will serve as a reference for those who are interested in aesthetic medicine but cannot take the first step to begin Rejuran with peace of mind.
What Is “Rejuran” in the First Place?

Attracting attention in recent years as a treatment that draws out the skin’s natural beauty is “Rejuran injection.” Without using a scalpel, by raising the skin’s own recovery power, an effect of regaining firmness and elasticity from within can be expected. Although it is a relatively new option in aesthetic medicine, it is already widely adopted in Korea, and its popularity is growing in Japan as well. Here we explain in detail Rejuran’s ingredients and effects, differences from other treatments, and the kind of people it suits.
Ingredients and Effects of Rejuran
Rejuran is an injectable with “polynucleotide (PN)” as its main ingredient. This PN is an ingredient extracted and purified from salmon DNA, characterized by high purity and biocompatibility. Because it has very high affinity with the human body and an extremely low risk of allergic reactions, it is attracting attention at aesthetic medical sites around the world as a highly safe ingredient.
Polynucleotide has the action of promoting the regeneration of cells in the body, and is expected especially in the dermis of the skin to help repair damaged tissue and regenerate cells. By injecting Rejuran into the skin, fibroblasts are activated and the production of components related to skin elasticity and firmness, such as collagen and elastin, is promoted. This changes the skin from within into skin with a plump texture.
Specifically, it draws out natural recovery against age-related changes such as lack of firmness, dryness, and fine lines, leading to smooth, elastic skin. It also works on open pores and coarse skin texture, so the overall impression of the skin becomes brighter and a youthful look is brought out.
Even More Effective in Combination with Potenza

Rejuran is a regenerative treatment that works on the skin with a different approach from hyaluronic acid and Botox.
Hyaluronic acid injection is effective for replenishing volume and physically lifting wrinkles, and Botox is a treatment that softens expression lines by suppressing muscle movement. Both have a high immediate effect and can be called “coping” methods that give change through external force.
Rejuran, on the other hand, works on the dermis of the skin and aims for “fundamental improvement of skin quality” by promoting repair and regeneration of the cells themselves. Rather than a superficial change, it is a treatment that regains skin firmness, elasticity, and moisture over time, and can be expected to rebuild skin damage from aging and UV rays from within.
In recent years, “delivery with Potenza” has attracted attention as a way to further raise the effect of Rejuran. Conventionally, “hand injection,” in which a doctor injects one spot at a time with a syringe, was mainstream, but with this method agent penetration tends to be uneven depending on the area, and it tends to depend on the practitioner’s skill.
In that respect, delivery using Potenza makes use of microneedles and radio frequency energy to make fine holes in the skin surface while delivering Rejuran evenly to the dermis. Because the agent can be made to penetrate evenly across the whole face, high satisfaction can be obtained in the beauty of the finish and natural firmness. The ability to finely adjust needle depth and irradiation strength also enables the optimal approach for skin type and concerns.
At Cleo Beauty Clinic, we recommend this Potenza delivery, aiming to draw out a more reliable effect by delivering the agent reliably while keeping the burden on the skin down. It is a treatment especially recommended for those who want to feel change gradually from within the skin, or who want a natural finish while keeping downtime down.
Why the Same Rejuran Differs by “Choice of Aesthetic Dermatology Clinic”

Rejuran is an excellent treatment that raises the skin’s regenerative power, but to draw out its effect to the maximum, “choosing an aesthetic dermatology clinic” — where you receive it — holds the key. Even with the same preparation, clear differences arise in the finish and satisfaction depending on the knowledge and technique of the side performing treatment, the quality of counseling, and consideration for safety.
Here we introduce, from three perspectives, the points to check when choosing an aesthetic dermatology clinic. The content will also be helpful for those considering Rejuran for the first time, so please use it as a reference.
Are the Appropriate Agents Used in Appropriate Amounts?
To clearly feel the effect of Rejuran, the type and quality of the agent used and the amount injected are very important. Even for treatments that look the same, the content and amount of agents used can differ greatly by aesthetic dermatology clinic.
At Cleo Beauty Clinic, we use the medical-institution-only “Rejuran Healer” and use a whole 2 cc in one treatment. This is our commitment to accurately observing the sufficient amount recommended by the manufacturer and drawing out the agent’s original power to the maximum.
On the other hand, at some aesthetic dermatology clinics, there are examples where the amount used is not clearly stated, or cosmetic-grade rather than medical-grade Rejuran is used. In such cases, while cost is kept down, it cannot be denied that the expected effect may not be sufficiently obtained.
If you want to produce solid results, it is important to check whether there is a reliable system for the selection and amount of agents. At our clinic, we clearly disclose the content and amount of agents and perform treatment after you are satisfied. We believe that a treatment environment with transparency and sincerity leads to reassurance and satisfaction.
Counseling Ability to Assess Skin Condition Is Also Important
Because Rejuran is a treatment that makes use of the skin’s natural healing power, it is very important not only to perform the treatment itself but to plan treatment after accurately assessing skin condition. The optimal injection amount and treatment frequency change depending on each person’s skin type, lifestyle, and past skincare history. Even so, an aesthetic dermatology clinic that makes the same proposal to everyone may not lead to a satisfying result.
For example, for people with strong dryness, combination with moisturizing care rather than Rejuran alone may be needed. For people concerned about acne scars or redness, combination with another treatment may be effective. Such judgments can only be made by a counselor with broad knowledge and experience who accurately analyzes skin condition.
Also, being thoroughly listened to at counseling resolves anxieties and questions and leads to receiving treatment with peace of mind. Choosing an aesthetic dermatology clinic that makes careful proposals suited to each person’s situation, rather than pushing treatment, is very important for nurturing the skin over the long term.
A Choice Without Regret Through Safety and Careful Explanation
Aesthetic medicine is a delicate field directly linked not only to visual change but to emotional satisfaction. For that reason, consideration for safety and an environment where you receive careful explanation until you are satisfied are indispensable.
Whether risks are properly explained in advance and whether precautions and aftercare after treatment are taught in detail are important points for telling whether an aesthetic dermatology clinic is reliable. In fact, not a few people have said they received treatment feeling anxious because the prior explanation was insufficient.
Also, whether there is a system in place to consult immediately when trouble arises is indispensable for continuing treatment safely. To build a trusting relationship with medical professionals, it is important to choose an aesthetic dermatology clinic that is easy to talk to and attentive.
Rather than deciding only by price, please be sure to check whether there is a “safe environment” in terms of attitude toward safety and carefulness of explanation.
Rejuran at Cleo Beauty Clinic in Shinsaibashi, Osaka

At Cleo Beauty Clinic, we have set up the system and environment so that even people new to aesthetic medicine can receive Rejuran treatment with peace of mind. Rejuran needs to be performed after assessing skin condition, with appropriate injection technique and safety management. At our clinic, doctors and nurses work together to propose the optimal treatment plan for each person’s skin condition and purpose.
Aesthetic Nurses with the Latest Knowledge and High Skill

At Cleo Beauty Clinic, the nurses in charge of Rejuran treatment are specialized aesthetic nurses who constantly update their technique and knowledge. To learn the latest theories and injection techniques on skin regeneration, they actively attend academic meetings and external training, and a system is in place to immediately reflect knowledge gained in the field in treatment.
Within the clinic as well, as a place for continuous technical improvement, we have established CLEO CLINICAL ACADEMY and regularly hold study sessions aimed at improving injection technique and counseling ability. Nurses give each other feedback and constantly explore “methods for drawing out the maximum effect.”

Cleo Beauty Clinic: 4 Minutes from Shinsaibashi Station, 3 Minutes from Nagahoribashi Station
Ease of visiting is very important for continuing treatment. Our clinic is located in an easy-to-reach place within a 5-minute walk of Shinsaibashi and Nagahoribashi stations, so you can visit on a schedule without strain, such as after work or between shopping.
Also, the calm atmosphere inside the clinic gives consideration to privacy, an environment where you can receive treatment relaxed. So that you can feel aesthetic medicine is close at hand, we value creating a space that combines ease of visiting with comfort.
Address
3F Tenshodo Building, 1-13-12 Higashi-Shinsaibashi, Chuo-ku, Osaka






