JUVGEN Cases at Our Clinic
Prices, Risks & Side Effects
Prices, Risks & Side Effects
| Prices | JUVGEN single session (2 weeks after completing the 1st of 2 sessions) Total: ¥88,000 |
| Risks & Side Effects | Temporary swelling, heat, and pain |
JUVGEN — The Cutting-Edge Nasolabial Fold Treatment
JUVGEN is a next-generation aesthetic medical device developed in Korea.
It is a treatment that promotes collagen regeneration by injecting tiny amounts of hyaluronic acid and carbon dioxide (CO₂) into the skin.
Conventional hyaluronic acid injections improve wrinkles by adding volume from the outside.
JUVGEN, on the other hand, takes
an approach that uses the skin’s own regenerative ability to increase dermal collagen and improve wrinkles and depressions
— a more fundamental approach.
For this reason, it is attracting attention as a treatment for deep nasolabial folds and for depressions that were difficult to improve with conventional treatments.
JUVGEN Case
Before treatment
Immediately after treatment (left side only)
One week after treatment
The nasolabial fold on the treated left side (right side as viewed) shows improvement.
Before
After
Before
After
Before
After
Before
After 5 years after treatment
The nasolabial fold has not returned over time.
This is the result of improving the nasolabial fold through regeneration of the patient’s own dermis.
JUVGEN Cases at Our Clinic
Prices, Risks & Side Effects
Prices, Risks & Side Effects
| Prices | JUVGEN single session (2 weeks after completing the 1st of 2 sessions) Total: ¥88,000 |
| Risks & Side Effects | Temporary swelling, heat, and pain |
Doctor’s Comment
The patient had been concerned about nasolabial folds since around age 30–40.
The examination found nasolabial folds caused by age-related volume loss.
The fold was deeper on the right than the left and extended below the corner of the mouth.
This case shows a photo taken two weeks after the first session.
The left nasolabial fold had improved significantly, and the patient noticed it as well.
Based on the response to the first session, the second session is performed with the amount adjusted.
Prices, Risks & Side Effects
Prices, Risks & Side Effects
| Prices | JUVGEN single session (2 weeks after completing the 1st of 2 sessions) Total: ¥88,000 |
| Risks & Side Effects | Temporary swelling, heat, and pain |
Doctor’s Comment
This case shows a photo taken two weeks after the first session.
The nasolabial fold has become lighter and the line itself has become shorter.
Doctor
Director Sara Motomura
- 6 years of experience in aesthetic dermatology
- 2023: Opened Cleo Beauty Clinic
- Currently: Director, Cleo Beauty Clinic
Qualifications
- Skincare Meister and Cosmetic Meister, Japan Cosmetic Association
- Botox Vista Certified Physician
- Juvederm Vista Certified Physician
- JPCA Personal Color Assistant Advisor
Memberships
- Japanese Society of Aesthetic Dermatology
- Medical Art Makeup Society
How Nasolabial Folds Form
Nasolabial folds are caused by a combination of age-related factors, and the following structural changes in the skin commonly occur.
- Decrease in dermal collagen
- Decline in skin elasticity
- Weakening of fat and skeletal support
- Loosening and sagging of ligaments
When these occur together, the skin loses its ability to support the fat in the midface, a fold forms as if the skin has been folded over, and fat appears to sit on top of it.
This is what a nasolabial fold is.
How JUVGEN Works
— Improving Nasolabial Folds Through Dermal Regeneration
JUVGEN is a treatment developed on the concept of self dermal regeneration (Dermal Regeneration).
Using a dedicated automatic injection device, extremely small amounts of
- hyaluronic acid
- and carbon dioxide (CO₂)
are injected into the dermal layer of the skin.
The following reactions then occur inside the skin.
- CO₂ promotes local blood flow
- A wound-healing response is induced
- Production of collagen and elastin is activated
- The skin is rebuilt from the inside
As a result,
the thickness and elasticity of the skin itself recover, and wrinkles and depressions improve.
Differences Between JUVGEN and Conventional Hyaluronic Acid
| JUVGEN | Conventional hyaluronic acid treatment | |
|---|---|---|
| Main action | Dermal regeneration (promotes collagen production) | Volume replacement (filling with hyaluronic acid) |
| How results appear | Gradual, natural change (several weeks to several months) | Immediate change |
| Finish | Very natural (improvement through regeneration of your own tissue) | Depending on the amount and area injected, swelling may occur |
| Approach | Rebuilds the dermis itself (addresses the underlying cause) | Fills grooves and depressions (symptomatic) |
| Duration | Long-term improvement can be expected (there are follow-up reports of results lasting several years) | Varies by product and individual (roughly 6 months to 1 year) |
| Safety | Mainly natural reactions, as it promotes regeneration of your own tissue | Because it remains in the body, there is a risk of lumps and blood flow disorders |
| Indications | Deep wrinkles and creases | Volume loss and depressions Nasolabial folds, tear troughs, etc. |
With JUVGEN, the hyaluronic acid is eventually absorbed.
However, the collagen your body produces in the process remains, so natural improvement tends to last.
